Title
Heavy Metal Poisoning and Cardiovascular Disease
Author
Eman M. Alissa & Gorden A. Ferns
Publication
Journal of Toxicology
Link
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168898/
Abstract
Cardiovascular disease (CVD) is an increasing world health problem. Traditional risk factors fail to account for all deaths from CVD. It is mainly the environmental, dietary and lifestyle behavioral factors that are the control keys in the progress of this disease. The potential association between chronic heavy metal exposure, like arsenic, lead, cadmium, mercury, and CVD has been less well defined. The mechanism through which heavy metals act to increase cardiovascular risk factors may act still remains unknown, although impaired antioxidants metabolism and oxidative stress may play a role. However, the exact mechanism of CVD induced by heavy metals deserves further investigation either through animal experiments or through molecular and cellular studies. Furthermore, large-scale prospective studies with follow up on general populations using appropriate biomarkers and cardiovascular endpoints might be recommended to identify the factors that predispose to heavy metals toxicity in CVD. In this review, we will give a brief summary of heavy metals homeostasis, followed by a description of the available evidence for their link with CVD and the proposed mechanisms of action by which their toxic effects might be explained. Finally, suspected interactions between genetic, nutritional and environmental factors are discussed.
Title
Cardiovascular Effects of lead Exposure
Author
Vaziri & Gonick
Publication
Indian Journal of Medical Research, Volume: 128 Source Issue: 4, October 1, 2008
Link
http://www.biomedsearch.com/article/Cardiovascular-effects-lead-exposure/192258138.html
Abstract
Lead in the body (Health aspects)
Cardiovascular diseases (Risk factors)
Hypertension (Risk factors)
Title
Effect of Lead on the Cardiovascular System
Author
Zyśko, Chlebda & Gajek
Publication
PMID
Link
http://www.ncbi.nlm.nih.gov/pubmed/15754646
Abstract
Lead is a metal widely spread in the natural environment. It is strongly toxic, particularly to the peripheral and central nervous systems. The toxic influence on the cardiovascular system is most pronounced in case of higher exposures, where myocardium and the renal circulation are affected, in consequence of which secondary arterial hypertension can develop. It seems that lead affects the cardiovascular system mainly by changing the peripheral autonomic nervous system and leading to chronic neuropathy. Chronic exposure, even to low doses of lead, can impair conduction in myocardium. In order to assess those changes thoroughly prospective studies involving newly employed workers with occupational exposure to toxic activity of lead will be necessary.
Title
Heavy Metal Poisoning and Cardiovascular Disease
Author
Eman M. Alissa & Gordon A. Ferns
Publication
Journal of Toxicology, Volume 2011 (2011), Article ID 870125, 21
Link
http://www.hindawi.com/journals/jt/2011/870125/
Abstract
Cardiovascular disease (CVD) is an increasing world health problem. Traditional risk factors fail to account for all deaths from CVD. It is mainly the environmental, dietary and lifestyle behavioral factors that are the control keys in the progress of this disease. The potential association between chronic heavy metal exposure, like arsenic, lead, cadmium, mercury, and CVD has been less well defined. The mechanism through which heavy metals act to increase cardiovascular risk factors may act still remains unknown, although impaired antioxidants metabolism and oxidative stress may play a role. However, the exact mechanism of CVD induced by heavy metals deserves further investigation either through animal experiments or through molecular and cellular studies. Furthermore, large-scale prospective studies with follow up on general populations using appropriate biomarkers and cardiovascular endpoints might be recommended to identify the factors that predispose to heavy metals toxicity in CVD. In this review, we will give a brief summary of heavy metals homeostasis, followed by a description of the available evidence for their link with CVD and the proposed mechanisms of action by which their toxic effects might be explained. Finally, suspected interactions between genetic, nutritional and environmental factors are discussed.
Title
Lead Exposure and Cardiovascular Disease–a Systematic Review
Author
Ana Navas-Acien, Eliseo Guallar, Ellen K Silbergeld, Stephen J Rothenberg
Publication
Environ Health Perspect,;115(3):472-82, March 22, 2007
Link
Abstract
Systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations.
Title
Lead Exposure and Cardiovascular Disease—Beyond Blood Pressure
Author
Navas-Acien, Guallar, Silbergeld & Rothenberg
Publication
Epidemiology, Volume 18 – Issue 5 – p S161, September 2007
Link
http://journals.lww.com/epidem/Fulltext/2007/09001/Lead_Exposure_and_Cardiovascular_Disease_Beyond.533.aspx
Abstract
This systematic review evaluates the evidence on the association between lead exposure and cardiovascular endpoints in human populations.